RESUMO
Intravenous leiomyomatosis (IVL) is a rare benign condition characterized by the proliferation of smooth muscle cells originating from either the uterine venous wall or a uterine myoma. This leiomyomatosis extends most frequently to pelvic vessels, but also occasionally into the inferior vena cava and right cardiac chambers. Preoperative diagnosis is difficult and it should be suspected in the presence of cardiac or pelvic masses in women who have undergone hysterectomy or myomectomy previously. The treatment is hysterectomy, normally associated with a bilateral oophorectomy and removing the mass or metastasis if any. The post-surgical follow-up should be performed at long-term and include exploration and imaging, either ultrasound or MRI. The association of antiestrogenic drugs can be useful for disease control, especially in cases where oophorectomy is not performed and the tumor cannot be removed completely.
Assuntos
Leiomiomatose/patologia , Neoplasias Pulmonares/secundário , Neoplasias Uterinas/patologia , Neoplasias Vasculares/patologia , Adulto , Feminino , Humanos , Histerectomia , Leiomiomatose/cirurgia , Neoplasias Pulmonares/terapia , Ovariectomia , Miomectomia Uterina , Neoplasias Uterinas/cirurgia , Neoplasias Vasculares/cirurgia , VeiasAssuntos
Eletrocoagulação , Doenças Fetais/cirurgia , Pentalogia de Cantrell/cirurgia , Redução de Gravidez Multifetal , Adulto , Feminino , Doenças Fetais/diagnóstico por imagem , Humanos , Medição da Translucência Nucal , Pentalogia de Cantrell/diagnóstico por imagem , Gravidez , Redução de Gravidez Multifetal/métodos , Gravidez de Gêmeos , Cordão UmbilicalRESUMO
INTRODUCTION: Granular cells tumor (GCT) is a rare tumor that develops on skin and soft tissues. Only 1-2% of these tumors present malignant behavior. MATERIAL AND METHODS: The authors report three cases of GCT and review the management of these tumors. CASE REPORT: The first case is a 73-year-old woman who was diagnosed with an atypical GCT. She was treated with local excision and then presented a local recurrence 21 months after the surgery. The other two cases are 60- and 58-year-old women diagnosed with a benign GCT. They were treated with single excision; both patients underwent second surgery due to margin affectation. CONCLUSION: Management of GCT is not clear nowadays. The careful selection of patients with poor prognostic factors is very important. Follow-up for early diagnosis of local recurrence and metastases of these tumors is of utmost importance.
Assuntos
Tumor de Células Granulares/patologia , Neoplasias Vulvares/patologia , Idoso , Feminino , Tumor de Células Granulares/cirurgia , Humanos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasias Vulvares/cirurgiaRESUMO
A series of 3-substituted (aryloxy)silane derivatives of benzylamine (4, 4', or 4") was synthesized and evaluated for hypocholesterolemic activity. Most of the new silane derivatives were identified as potent inhibitors of pig liver squalene epoxidase with IC50 values in the submicromolar range. In vitro inhibition of cholesterol biosynthesis in Hep-G2 cells was observed with a very good potency for the ene-yne derivatives 4a, 4i, 4n, 4q, and 4u as well as for the yne-yne compound 4". In vivo, 4i, 4u, 4', and 4" were found to decrease cholesterol biosynthesis in rats upon oral administration with ED50 values in the range of 2-7 mg/kg. Therefore, these new (aryloxy)methylsilane derivatives of benzylamine represent a new class of potent squalene epoxidase inhibitors with promising hypocholesterolemic properties.
